The way I use it:

Connection:

- Port used for incoming connections - Use a port that you have open or preferably a port between 20,000 and 65,000.
- Uncheck Enable UPnP Port Mapping

Bittorrent

- Global maximum number of connections: 500
- Maximum number of connected peers per torrent: 300
- Number of upload slots per torrent: 300
- Uncheck Enable DHT Network
- Uncheck Enable DHT for new torrent
- Uncheck Enable Peer Exchange
- Outgoing: Enabled
- Check - Allow incoming legacy connections