Kaspersky is best

Its funny, but I was using Windows Defender for a while... but now my favorite is Nod32.

I use Malwarebytes Premium along with Malwarebytes Anti-Exploit Premium and my PC runs smoothly, regarding NOD32 I know it's a little better than this one but it dramatically slows your computer down ... regarding anti-virus protection, If someones encrypts his virus with a private and good encryption and the virus is developed well you will certainly get that virus on your computer and even don't have a clue about it :-) maybe it will take months for the forensic malware lab to find it and it's signature so basically what I'm trying to say ... even if you have a great anti-virus on your PC you have a 80-90 percent chance in getting infected ... on the other hand, bad software development allow a lot of bad things to happen ... to have a grasp on all the things that i've said in here take a look at this great article

I don't use an Antivirus, instead I keep all my stuff in the cloud and on NAS drives. If something hits I just reinstall my computer. Antiviruses are always a step behind anyway.

Security Essentials has done a good job over the last few years now, small memory footprint and doesn't interfere with things. Used to use Norton but it started to slow my system down too much. I've had to fix a number of PCs over the years that were running AVG as it had a habit of killing internet connections on a few of it's automatic updates.

from my experience
kaspersky is the best

The best is just using you own judgement. I haven't had any antivirus software since I was 10. I never get Virus's.
Every time I run a scan they find all my crack files and stuff and try to get rid of them.

There is no best antivirus. It depends on what you are looking for.
I use EsetNod

Mac user

I've been using NOD32 since quite sometime and it hasn't disappointed me.