Captain William T. Riker - U.S.S. Titan
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Commander Will Riker (Jonathan Frakes) served as the First Officer on the U.S.S. Enterprise-D for 15 years and he famously turned down several promotions to command his own ship, including the U.S.S. Drake, the U.S.S. Aries, and the U.S.S. Melbourne. But by 2379, with Jean-Luc Picard still having no intention of relinquishing command of the Enterprise-E, Riker made pivotal life decisions: He married his Imzadi, Counselor Deanna Troi (Marina Sirtis), and it was finally time for Will to accept a long-delayed promotion to Captain. Riker moved on to command the U.S.S. Titan, which he and Troi took over after Star Trek: Nemesis. In Star Trek: Picard's era 20 years later, Riker is semi-retired but he took command of the U.S.S. Zheng He to rescue Jean-Luc and the synthetics living on the planet Coppelius from a Romulan invasion.
Captain Carol Freeman - U.S.S. Cerritos
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The newest Star Trek TV series, Star Trek: Lower Decks introduced Captain Carol Freeman (Dawnn Lewis), who commands the California-class U.S.S. Cerritos. Since the animated comedy centers on the junior officers of the Cerritos, including Freeman's daughter Beckett Mariner (Tawny Newsome), Star Trek: Lower Decks has yet to reveal how Freeman gained command of the Cerritos, which specializes in Second Contact missions, but she feels her and her starship are deserving of better things.
Captain Worf - U.S.S. Enterprise-E
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Although it hasn't been seen or spoken of in a Star Trek TV series (yet), Worf (Michael Dorn) is the new Captain of the U.S.S. Enterprise-E in Star Trek: Picard's era according to the CBS All-Access series' canonical tie-in novel Star Trek: Picard: The Last Best Hope by Una McCormack. When the Romulan sun went supernova, Jean-Luc Picard accepted a promotion to Admiral in order to lead the Federation's rescue fleet to save the Romulan people. Picard relinquished command of the Enterprise to his First Officer, Worf, despite Starfleet's objections due to a black mark on his record the Klingon obtained during his time on Star Trek: Deep Space Nine.
Captain Cristobal Rios - La Sirena
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Cristobal Rios doesn't command a Starfleet ship but he was a former C0mmander who served on the U.S.S. ibn Majid. After a tragedy where his Captain, Alonzo Vandemeer, murdered two synthetic ambassadors from the planet Coppelius, and then committed suicide, Rios covered up the incident and was subsequently discharged from Starfleet. Rios took over the starship La Sirena as her Captain but he later took on a motley crew, including retired Admiral Jean-Luc Picard, as seen in Star Trek: Picard season 1.