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Adelaide University investigates treating chronic inflammation may tackle depression
TREATING chronic inflammation could improve outcomes for patients with depression, researchers at the University of Adelaide have proposed.
The study – the only one of its kind in the world – is investigating a novel treatment in depression by adding anti-inflammatory medication to usual antidepressant treatment and is looking for participants.
About two thirds of people suffering from depression won’t have improvement on antidepressant medication and it is hoped identifying those with inflammatory blood level markers will improve this rate.
Blood levels of inflammatory markers have been found to be mildly elevated in some people with depression.
It is hoped that the results of this work will eventually help to guide personalised treatment decision making for depression.
This would mean GPs would be able to determine the best course of treatment by a blood test result.
Professor Bernhard Baune said the study would build on more than two decades of research into the link between inflammation and depression.
“Proteins of inflammation in the blood stream, called cytokines, can induce symptoms of depression in humans and depression-like behaviour in small animals,’’ Prof Baune said.
“Inflammation can cause depression (through) injection of cytokines into the peripheral blood,which leads to symptoms relevant to depression such as sleep problems, cognitive problems, reduced concentration and memory; low mood; vegetative symptoms, and appetite issues.”
Prof Baune said whether depression directly or independently lead to inflammation remained far less clear.
“However people with depression have generally a poorer lifestyle with less exercise, unhealthy diet and poor sleep, all of which are associated with stronger inflammation,” he said.
“In addition, people with depression often suffer from poor stress response management, which (if stress is poorly responded to) is a risk factor for the development of inflammation.”
To be eligible for the study, participants must be aged between 18-75 years of age, with current Major Depressive Disorder.
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