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Thread: Peptide could allow medical marijuana to relieve pain without side effects

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    Peptide could allow medical marijuana to relieve pain without side effects

    Many people live with chronic pain, and in some cases, cannabis can provide relief. But the drug also can significantly impact memory and other cognitive functions. Now, researchers reporting in ACS' Journal of Medicinal Chemistry have developed a peptide that, in mice, ∆9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, to fight pain without the side effects.

    According to the U.S. Centers for Disease Control and Prevention, about 20% of adults in the U.S. experienced chronic pain in 2019. Opioids, the mainstay for severe pain management, are effective, but patients can easily become addicted to them. In some studies, medical marijuana has been helpful in relieving pain from migraines, neuropathy, cancer and other conditions, but the side effects present hurdles for widespread therapeutic use. Previously, researchers identified two peptides that disrupt an interaction between a receptor that's the target of THC and another receptor that binds serotonin, a neurotransmitter that regulates learning, memory and other cognitive functions. When the researchers injected the peptides into the brains of mice, the mice had fewer memory problems caused by THC. Now, this team, led by Rafael Maldonado, David Andreu and colleagues, wanted to improve these peptides to make them smaller, more stable, orally active and able to cross the blood-brain barrier.

    Based on data from molecular dynamic simulations, the researchers designed two peptides that were less than half the length of the original ones but preserved their receptor binding and other functions. They also optimized the peptide sequences for improved cell entry, stability and ability to cross the blood-brain barrier. Then, the researchers gave the most promising peptide to mice orally, along with a THC injection, and tested the mice's pain threshold and memory. Mice treated with both THC and the optimized peptide reaped the pain-relieving benefits of THC and also showed improved memory compared with mice treated with THC alone. Importantly, multiple treatments with the peptide did not evoke an immune response. These findings suggest that the optimized peptide is an ideal drug candidate for reducing cognitive side effects from cannabis-based pain management, the researchers say.
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    legalize it bruh
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    Medicine takes a significant role in our society because it helps to improve health. Anyway, I do not know how to get rid of this anxiety and I asked my friend for advice for having suffered the same problem with her health. He advised me to visit this fountain https://www.westcoastsupply.net/prod...ijuana/hybrid/ in order to examine various cannabis products like hybrid. I compared all the drugs presented in this store and bought one that helped me alleviate my suffering after a few hours from the beginning of use. If you are still looking for a remedy for additional stress, you can also visit this site and probably order a product.

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    I understand your feelings and as for me, one friend of mine has recommended me to check this super glue strain review on https://askgrowers.com/strains/super-glue-strain-review because smoking such strains really helps him all the time so it seems to me that I also need to try it on my own... What do you think?
    Last edited by donny9; 09-05-2022 at 02:57 PM.


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