Microsoft Security Essentials , or no anti-virus at all.
Sophisticated AV slows down the performance and breaks functionality sometimes. The 0-day viruses are not detected by AV anyway. So I don't think there is much benefit to have sophisticated AV installed other than the very basic to perform a scan on some files you think are suspicious.
The best AV is yourself - Don't expose yourself to the threat. (avoid unsafe sites and files)