COMEDIAN Will Ferrell was in a serious car accident in Orange County, California last night.

The Hollywoods star was travelling down the I-5 freeway in a chauffeur-driven SUV, where he was side-swiped before it flipped over.

TMZ reports that the Zoolander star, 50, was one of three passengers in the car when the accident happened around 11pm local time (4pm AEST).

The Orange County Fire Authority, which responded to the scene, told Fox News that the accident involved two vehicles, a sedan and a limo SUV, and that all three passengers were taken to the hospital with minor injuries.

A woman was taken to a different hospital to be treated for trauma and the driver of the sedan was not transported to the hospital.

Video from the scene showed a black SUV on its side on the road. The video also captured the star on the phone while being lifted into an ambulance.

Photos also showed him looking shaken up, but stable as he was seen making a phone call while on a stretcher with paramedics who put him in an ambulance.