Two people have been killed and two injured after a small plane crashed into a Southern California house in the United States.

Fire authorities said the crash on Sunday afternoon local time ignited a house in Yorba Linda, a suburban city in Orange County located about 60km from Los Angeles.

Video posted on Twitter showed panicked residents running to a suburban home that was engulfed in flames.

Images also showed a propeller scattered across a driveway.

There was no immediate information on the extent of the injuries, and whether the people killed were on board the plane or on the ground.

The US Federal Aviation Administration said the twin-engine Cessna 414A crashed in Yorba Linda shortly after taking off from the Fullerton Municipal Airport.

More to come