A MUM and dad who have already suffered the heartache of losing three of their children to a rare genetic disease now face losing their daughter to the same fate.

Little Jade Lake suffers from Leigh's syndrome, a severe neurological disorder that has no cure.

Her parents, Craig and Adele, watch on hopelessly knowing each day could be her last.

Every year Jade, who is eight but has the mental age of just two, hangs three angels on her family Christmas tree to represent her lost siblings.

She doesn't know the decorations are tributes to her brothers and sisters, nor does she know about her genetic condition that will one day kill her.

"We take it day by day," dad Craig told GrimsbyLive.

"She might go to bed one night and not wake up."

The 46-year-old has already carried the coffin of three of his children and knows the dreadful ritual will be repeated one last time.

Angel died aged three in 2011, AJ died aged just three months in 2014 and just a year later Jasmine died aged nine.

Little Jade is their only surviving child but her time is quickly running out.

For now, Craig and Adele have no idea how long they have left with their daughter.

Adele, 33, carries the deadly gene that was passed onto her daughter.

Leigh's syndrome has affected Jade's mental age, left her with a poor memory and suffering constant fatigue.

A small illness like a cold could be enough to kill her, but at age eight she is considered "long lived".

She is the first child of Craig and Adele's to walk and talk.

The couple are focusing on making memories with Jade.

"We just can't predict the future. All we know is that she is becoming more and more tired," Craig said.

Their first child, Angel, died in Craig's arms after falling ill just two days earlier.

Their son AJ died within 12 hours of developing a high temperature.

Jasmine suffered an agonising 38 day death.

Having lived through that heartache, the couple are constantly aware of Jade's health, worrying every time she falls ill.

Their most recent scare was in September when Jade's temperature soared.

The couple said none of their children have been planned, but they don't believe in abortion so they've carried each on to term desperately hoping the disease wouldn't be passed on.

The ashes of their three other children lay next to their favourite teddies in their Grimsby home

"For us, they are still ours," Craig said.

"They are still here. They are still part of us. They should be with their family no matter what - in life or in death."