AT LEAST 24 people were killed and another 19 injured when a bus careened into another vehicle at high speed and overturned on a highway near Ecuador’s capital, local officials reported.

The Colombian-registered bus was travelling to Quito and hit a smaller vehicle in an area known as dead man’s curve at about 3am (6pm AEST), Ecuadorean authorities said.

Quito district security secretary Juan Zapata told Colombia’s Blu Radio that Colombian and Venezuelan nationals were among the dead.

Two minors travelling in the smaller vehicle were also killed.

A small fleet of ambulances and first responders rushed to the crash site about two hours from Quito before dawn.

They found the severely wrecked bus overturned and several homes adjacent to the highway damaged and strewn with metal debris.