Chelsea striker Diego Costa and Manchester City's Nolito scored as Spain beat Albania to top Group G in qualifying for the 2018 World Cup.
Premier League players David de Gea, Nacho Monreal and David Silva all featured for Spain in the 2-0 win.
In the same group, Italy needed a 91st-minute winner from Ciro Immobile to come from behind and beat Macedonia.
Lazio striker Immobile earlier equalised for Italy against the team ranked 146th in the world.
Elsewhere in Group G, Israel beat Liechtenstein 2-1 with Brighton striker Tomer Hemed scoring both goals for the hosts.
Newcastle United striker Aleksandar Mitrovic scored twice, before Southampton midfielder Dusan Tadic netted the winner, as Serbia beat Austria 3-2.
Serbia lead Group D ahead of the Republic of Ireland and Wales.
Croatia top Group I after Juventus striker Mario Mandzukic gave them a 1-0 away win against Finland.
Iceland are second following a 2-0 victory over Turkey and in the same group, Ukraine beat Kosovo 3-0.