Australia have entered uncharted territory as they enter the final stages of their World T20 preparations.

The 15-player squad flew from Antigua to the South American nation of Guyana on Sunday, their base for the next two weeks as their bid to win back the 20-over world crown begins in earnest.

The Caribbean is already unfamiliar territory for Australia's women's team who have visited the region on just two previous occasions; for a Test series in 1976 and for their successful World T20 campaign in 2010.

From that 2010 winning squad, four members have returned for the 2018 bid: Alyssa Healy, Ellyse Perry, Elyse Villani and Rachael Haynes.

Guyana, a nation of fewer than one million people bordered by Venezuela, Brazil and Suriname – and perhaps best known for the Kaieteur Falls, the world's largest single drop waterfall – has never hosted Australia's women, but Villani said she was eager to see what awaited the squad in their new base of Georgetown, and at Providence Stadium where they'll play all four of their group matches.

On Monday, Australia will have their first look at Providence Stadium during an afternoon training session, ahead of a warm-up match against South Africa on Tuesday.

Australia's first practice match against England in Antigua was washed out without a ball being bowled on Saturday, while South Africa were soundly beaten by Pakistan in their own warm-up.

Meg Lanning's team would have been ruing the missed chance to test themselves against a fellow tournament favourite in England, but the Proteas boast a strong squad including Rebel WBBL players Dane van Niekerk, Marizanne Kapp, Lizelle Lee, Mignon du Preez, Laura Wolvaardt and Sune Luus.

"They're a strong side and they've got some outstanding match winners in their team," Villani said ahead of Australia's departure on Sunday.

"They've played a lot of Big Bash particularly for the Sydney Sixers so they're not unfamiliar opposition but they're definitely individuals who we are aware of and who can be very dangerous.

"We would have liked to have gotten on against the English, but I think we've had a pretty good lead up in series against Pakistan.

"Now it's just about fine-tuning things and really looking at our opposition and making sure we've out our plans in place, and utilising our training sessions we've got left in to work on the things we think are important as individuals and from a team perspective to put the finishing touches on."

With their jet-lag now well and truly behind them, it's all systems go for Australia this week with three training sessions and the warm-up against the Proteas all that's left standing between them and their opening match of the tournament proper against Pakistan on Friday (Saturday 7am AEDT).

The hectic pace of the tournament will see Australia play Pakistan, Ireland and New Zealand in the space of five days, all at Providence Stadium, with a three-day break to follow before their final group match against India.

There's little room for error with only the top two teams to advance to the semi-finals in Antigua, something coach Matthew Mott is well aware of.

"It's tournament play, it's very cut throat and you don't have the luxury in T20 of too many bad 20-minute periods," Mott said in Antigua on Friday.

Australia's warm-up against South Africa will kick off at 4pm Tuesday local time (Wednesday 7am AEDT).

Once the tournament proper gets underway, Fox Sports will broadcast every match of the Women's World T20, while the Nine Network will televise Australia's matches.