England lock George Kruis is out of the Six Nations opener against France on Saturday with a knee ligament injury.

The 26-year-old Saracens second row suffered the injury in training on Tuesday and will see a specialist on Thursday to determine its severity.

England head coach Eddie Jones said: "We are not ruling him out of the Six Nations at this stage."

Courtney Lawes and Joe Launchbury are now expected to pair up in the second row, with Maro Itoje at flanker.